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Research article2006Peer reviewed

Protective effect of vaccination with recombinant proteins from Streptococcus equi subspecies equi in a strangles model in the mouse

Flock M, Karlstrom A, Lannergard J, Guss B, Flock JI

Abstract

A mouse model resembling Streptococcus equi subspecies equi infection in the horse, strangles, was used to assess the protective effect of vaccination with selected recombinant proteins from S. equi subsp. equi. After challenge the infection was monitored by weight loss and by nasal colonisation with S. equi subsp. equi. Vaccination with a collagen-binding protein (CNE) and a collagen-like protein (ScIC) resulted in protective antibodies, whereas a novel fibronectin-binding protein (FNEB) did not. Co-administration of CNE with EAG, a poorly immunogenic alpha(2)-macroglobulin-, albumin- and immunoglobulin G-binding protein, resulted in a significant synergistic effect and enhanced the protective immune response against EAG. (c) 2006 Elsevier Ltd. All rights reserved

Published in

Vaccine
2006, Volume: 24, number: 19, pages: 4144-4151
Publisher: ELSEVIER SCI LTD

      SLU Authors

      • UKÄ Subject classification

      Animal and Dairy Science
      Veterinary Science

      Publication identifier

      DOI: https://doi.org/10.1016/j.vaccine.2006.02.016

      Permanent link to this page (URI)

      https://res.slu.se/id/publ/8170