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Research article - Peer-reviewed, 2017

Diagnostic possibilities from a serum sampleClinical value of new methods within small animal reproduction, with focus on anti-Mullerian hormone

Holst, B. S.

Abstract

Contents During the last decade, analysis of anti-Mullerian hormone (AMH), highly conserved between mammalian species, has contributed to new information in reproductive endocrinology, due to clinically available diagnostic assays. AMH is produced solely in the gonads, in the Sertoli cells of testes and granulosa cells of the ovary, and thus offers possibilities to diagnose physiologic and pathologic conditions involving these organs. This article reviews indications for AMH analysis in cats and dogs, including diagnosing the presence of gonads, and granulosa or Sertoli cell tumours. Diagnostic challenges are addressed. One specific organ, the prostate, is commonly affected by pathologic changes in older dogs. A commercial assay for analysing canine prostatic specific esterase (CPSE) enables analysis of CPSE in clinical practice, of potential value in the workup of benign prostatic hyperplasia in male dogs. This is described in this review, as is a new method for analysis of steroids: liquid chromatography-tandem mass spectrometry LC-MS/MS. Steroids have since long been analysed in studies on reproduction, and LC-MS/MS has the advantage of allowing analysis of panels of multiple steroids from small sample volumes. Altogether, these available methods may give new insights into small animal reproduction and are valuable tools for the practicing veterinarian.

Keywords

AMH; BPH; castration; LC-MS; MS

Published in

Reproduction in Domestic Animals
2017, volume: 52, number: Suppl. 2, pages: 303-309
Publisher: WILEY

Authors' information

Swedish University of Agricultural Sciences, Department of Clinical Sciences

UKÄ Subject classification

Clinical Science

Publication Identifiers

DOI: https://doi.org/10.1111/rda.12856

URI (permanent link to this page)

https://res.slu.se/id/publ/82571