Serum Trimethylamine-N-Oxide Is Strongly Related to Renal Function and Predicts Outcome in Chronic Kidney Disease

Abstract

BackgroundThe microbial metabolite Trimethylamine-N-oxide (TMAO) has been linked to adverse cardiovascular outcome and mortality in the general population.ObjectiveTo assess the contribution of TMAO to inflammation and mortality in chronic kidney disease (CKD) patients ranging from mild-moderate to end-stage disease and 1) associations with glomerular filtration rate (GFR) 2) effect of dialysis and renal transplantation (Rtx) 3) association with inflammatory biomarkers and 4) its predictive value for all-cause mortality.MethodsLevels of metabolites were quantified by a novel liquid chromatography/tandem mass spectrometry-based method in fasting plasma samples from 80 controls and 179 CKD 3-5 patients. Comorbidities, nutritional status, biomarkers of inflammation and GFR were assessed.ResultsGFR was the dominant variable affecting TMAO (beta = -0.41; p

Published in

PLoS ONE
2016, volume: 11, number: 1, article number: e0141738
Publisher: PUBLIC LIBRARY SCIENCE

SLU Authors

• Hällqvist, Jenny

  • Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences
    

Global goals (SDG)

SDG3 Good health and well-being

UKÄ Subject classification

Clinical Medicine

Publication identifier

• DOI: https://doi.org/10.1371/journal.pone.0141738

Permanent link to this page (URI)

https://res.slu.se/id/publ/83280