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Research article2017Peer reviewedOpen access

Markers of Oxidative Stress in Dogs with Myxomatous Mitral Valve Disease are Influenced by Sex, Neuter Status, and Serum Cholesterol Concentration

Reimann, M. J.; Haggstrom, J.; Moller, J. E.; Lykkesfeldt, J.; Falk, T.; Olsen, L. H.

Abstract

Background: Cardiovascular disease has been associated with oxidative stress, which has been suggested to contribute to myocardial remodeling in human patients. Little is known about the relationship between myxomatous mitral valve disease (MMVD) and oxidative stress in dogs.Objective: To determine whether clinical stage of MMVD is associated with changes in the plasma concentrations of certain markers of oxidative stress in clinically healthy dogs and dogs with MMVD.Animals: Seventy five privately owned dogs: 59 cavalier King Charles Spaniels (CKCS) with different severities of MMVD and 16 dogs of different breeds with clinical signs of congestive heart failure (CHF) caused by MMVD.Methods: Markers of oxidative stress including malondialdehyde (MDA), oxidized low-density lipoprotein (oxLDL), and vitamin E (alpha-tocopherol and gamma-tocopherol) were measured in plasma and their association with clinical stage of MMVD was assessed by regression analyses.Results: Plasma oxLDL concentration was significantly lower in female dogs compared with males (P = .01). Significantly higher plasma gamma-tocopherol concentrations were found in neutered (P = .003) dogs. Vitamin E (alpha-tocopherol [P = .0004] and gamma-tocopherol [P = .003]) was associated with body condition score (BCS), but the association disappeared when cholesterol was included in the analyses. All markers of oxidative stress (MDA, oxLDL, and vitamin E) were positively associated with serum cholesterol concentration (P = .04), but none were associated with clinical stage of MMVD.Conclusions: In conclusion, markers of oxidative stress are associated with sex, BCS, neuter status, and cholesterol. The results cannot confirm a relationship between oxidative stress and clinical stage of the disease in dogs with MMVD.

Keywords

Malondialdehyde; Oxidized low-density lipoprotein; Valvular disease; Vitamin E

Published in

Journal of Veterinary Internal Medicine
2017, Volume: 31, number: 2, pages: 295-302

    UKÄ Subject classification

    Cardiac and Cardiovascular Systems

    Publication identifier

    DOI: https://doi.org/10.1111/jvim.14647

    Permanent link to this page (URI)

    https://res.slu.se/id/publ/83722