Research article2006Peer reviewed
Thyroid receptor ligands. 6. A high affinity "direct antagonist" selective for the thyroid hormone receptor
Koehler, Konrad; Gordon, Sandra; Brandt, Peter; Carlsson, Bo; Backsbro-Saeidi, Anna; Apelqvist, Theresa; Agback, Peter; Grover, Gary J.; Nelson, William; Grynfarb, Marlena; Farnegardh, Mathias; Rehnmark, Stefan; Malm, Johan
Abstract
A new high-affinity thyroid hormone antagonist 6 with druglike properties was designed and synthesized. The compound behaved as an antagonist in a cell transactivation assay, and in a first in vivo experiment in rats.
Published in
Journal of Medicinal Chemistry
2006, Volume: 49, number: 23, pages: 6635-6637
Publisher: AMER CHEMICAL SOC
UKÄ Subject classification
Organic Chemistry
Publication identifier
DOI: https://doi.org/10.1021/jm060521i
Permanent link to this page (URI)
https://res.slu.se/id/publ/83871