Particulate matter air pollution components and risk for lung cancer

Raaschou-Nielsen, O.; Beelen, R.; Wang, M.; Hoek, G.; Andersen, Z. J.; Hoffmann, B.; Stafoggia, M.; Samoli, E.; Weinmayr, G.; Dimakopoulou, K.; Nieuwenhuijsen, M.; Xun, W. W.; Fischer, P.; Eriksen, K. T.; Sorensen, M.; Tjonneland, A.; Ricceri, F.; De Hoogh, K.; Key, T.; Eeftens, M.; Peeters, P. H.; Bueno-de-Mesquita, H. B.; Meliefste, K.; Oftedal, B.; Schwarze, P. E.; Nafstad, P.; Galassi, C.; Migliore, E.; Ranzi, A.; Cesaroni, G.; Badaloni, C.; Forastiere, F.; Penell, J.; De Faire, U.; Korek, M.; Pedersen, N.; Ostenson, C. -G.; Pershagen, G.; Fratiglioni, L.; Concin, H.; Nagel, G.; Jaensch, A.; Ineichen, A.; Naccarati, A.; Katsoulis, M.; Trichpoulou, A.; Keuken, M.; Jedynska, A.; Kooter, I. M.; Kukkonen, J.; Brunekreef, B.; Sokhi, R. S.; Katsouyanni, K.; Vineis, P.

doi:10.1016/j.envint.2015.11.007

Research article2016Peer reviewedOpen access

Particulate matter air pollution components and risk for lung cancer

Raaschou-Nielsen, O.; Beelen, R.; Wang, M.; Hoek, G.; Andersen, Z. J.; Hoffmann, B.; Stafoggia, M.; Samoli, E.; Weinmayr, G.; Dimakopoulou, K.; Nieuwenhuijsen, M.; Xun, W. W.; Fischer, P.; Eriksen, K. T.; Sorensen, M.; Tjonneland, A.; Ricceri, F.; De Hoogh, K.; Key, T.; Eeftens, M.;
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Abstract

Background: Particulate matter (PM) air pollution is a human lung carcinogen; however, the components responsible have not been identified. We assessed the associations between PM components and lung cancer incidence.Methods: We used data from 14 cohort studies in eight European countries. We geocoded baseline addresses and assessed air pollution with land-use regression models for eight elements (Cu, Fe, K, Ni, S, Si, V and Zn) in size fractions of PM2.5 and PM10. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effect models for meta-analysis.Results: The 245,782 cohort members contributed 3,229,220 person-years at risk. During follow-up (mean, 13.1 years), 1878 incident cases of lung cancer were diagnosed. In the meta-analyses, elevated hazard ratios (HRs) for lung cancer were associated with all elements except V; none was statistically significant In analyses restricted to participants who did not change residence during follow-up, statistically significant associations were found for PM2.5 Cu (HR, 125; 95% Cl, 1.01-1.53 per 5 ng/m(3)), PM10 Zn (1.28; 1.02-1.59 per 20 ng/m3), PMio S (1.58; 1.03-2.44 per 200 ng/m(3)), PM10 Ni (1.59; 1.12-2.26 per 2 ng/m(3)) and PM10K (1.17; 1.02-1.33 per 100 ng/m(3)). In two-pollutant models, associations between PMio and PM2.5 and lung cancer were largely explained by PM2.5 S.Conclusions: This study indicates that the association between PM in air pollution and lung cancer can be attributed to various PM components and sources. PM containing S and Ni might be particularly important. (C) 2015 Elsevier Ltd. All rights reserved.

Keywords

Air pollution; Particulate matter; Sulfur; Nickel; Cohort study; Lung cancer

Published in

Environment International
2016, Volume: 87, pages: 66-73
Publisher: PERGAMON-ELSEVIER SCIENCE LTD

UKÄ Subject classification

Public Health, Global Health, Social Medicine and Epidemiology
Environmental Health and Occupational Health

Publication identifier

DOI: https://doi.org/10.1016/j.envint.2015.11.007

Permanent link to this page (URI)

https://res.slu.se/id/publ/83988