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Research article - Peer-reviewed, 2000

Relationship between different natriuretic peptides and severity of naturally acquired mitral regurgitation in dogs with chronic myxomatous valve disease

Häggström, Jens; Hansson, Kerstin; Kvart, Clarence; Duelund Pedersen, Henrik; Vuolteenaho, Olli; Olsson, Kerstin

Abstract

Objective
To study the responses of atrial natriuretic peptide (ANP), N-terminal fragment of pro-atrial natriuretic peptide (NT-proANP) and brain natriuretic peptide (BNP) to varying severity of mitral regurgitation (MR) in dogs with myxomatous valve disease (MVD).

Design
Case-control.

Dogs
103 Cavalier King Charles Spaniels, 27 normal individuals and 76 with varying degree of MR.

Procedure
Dogs were evaluated by physical examination, collection of venous blood, thoracic radiography and echocardiography. NT-proANP, ANP and BNP were measured in plasma using radio immunoassay (RIA).

Results
The mean concentrations of NT-proANP were 37.4 and 83.5 times higher than ANP and BNP, respectively. The mean ANP to BNP molar ratio was 2.6. Plasma concentrations of NT-proANP and ANP were slightly increased in asymptomatic dogs with increased cardiac dimensions; those with signs of decompensated heart failure (HF) had mean concentrations of NT-proANP and ANP 3 to 7 times higher than normal dogs. The BNP concentrations were increased only in dogs with decompensated HF and the levels were approximately twice as high in these dogs as in normal individuals. Univariate and multiple regression analysis showed that primarily left atrial and ventricular size influenced the plasma concentrations of all 3 peptides (increased with increasing measurement). Analyses of response operating characteristic (ROC) curves indicated that NT-proANP and ANP were more discriminating than BNP for either cardiomegaly of HF.

Clinical Implications
Natriuretic peptides, particularly NT-proANP and ANP, may be of benefit in the overall assessment of dogs with naturally occurring MR. Analysis of NT-proANP may be more useful than ANP owing to easier handling of the samples and less laborious assay.

Published in

Journal of Veterinary Cardiology
2000, volume: 2, number: 1, pages: 7-16

Authors' information

Swedish University of Agricultural Sciences, Department of Animal Physiology
Swedish University of Agricultural Sciences, Department of Clinical Radiology
Swedish University of Agricultural Sciences, Department of Animal Physiology
Duelund Pedersen, Henrik
Royal Veterinary and Agricultural University
Vuolteenaho, Olli
University of Oulu
Olsson, Kerstin
Swedish University of Agricultural Sciences, Department of Animal Physiology

UKÄ Subject classification

Clinical Science

Publication Identifiers

DOI: https://doi.org/10.1016/S1760-2734(06)70002-9

URI (permanent link to this page)

https://res.slu.se/id/publ/83994