Ingvarsson, Pär
- Umeå University
Abstract
Economically important traits in many species generally show polygenic, quantitative inheritance. The components of genetic variation (additive, dominant and epistatic effects) of these traits conferred by multiple genes in shared biological pathways remain to be defined. Here, we investigated 11 full-length genes in cellulose biosynthesis, on 10 growth and wood-property traits, within a population of 460 unrelated Populus tomentosa individuals, via multi-gene association. To validate positive associations, we conducted single-marker analysis in a linkage population of 1,200 individuals. We identified 118, 121, and 43 associations (P < 0.01) corresponding to additive, dominant, and epistatic effects, respectively, with low to moderate proportions of phenotypic variance (R-2). Epistatic interaction models uncovered a combination of three non-synonymous sites from three unique genes, representing a significant epistasis for diameter at breast height and stem volume. Single-marker analysis validated 61 associations (false discovery rate, Q
Keywords
Chinese white poplar (Populus tomentosa); epistasis; pathway-based multiple gene association; transcript profiling; validation population
Published in
DNA Research
2015, volume: 22, number: 1, pages: 53-67
Publisher: OXFORD UNIV PRESS
SLU Authors
UKÄ Subject classification
Genetics and Genomics
Publication identifier
- DOI: https://doi.org/10.1093/dnares/dsu040
Permanent link to this page (URI)
https://res.slu.se/id/publ/84110