Synthesis of 5-deoxy-5-phospho-D-ribonohydroxamic acid: a new competitive and selective inhibitor of type B ribose-5-phosphate isomerase from Mycobacterium tuberculosis

Sammanfattning

5-Deoxy-5-phospho-D-ribonohydroxamic acid, a mimic of the 1,2-cis-enediolate high-energy intermediate species of the allose-6-phosphate isomerase reaction, was obtained by a six-step synthesis from D-erythronolactone. In contrast to the known competitive ribose-5-phosphate isomerase (Rpi) inhibitors 4-deoxy-4-phospho-D-crythronohydroxamic acid, 4-deoxy-4-phospho-D-erythronate, and 4-deoxy-4-phosphonomethyl-D-erythronate, the new hydroxamic acid selectively inhibits Mycobacterium tuberculosis RpiB (K-i = 0.40 mM, K-m/K-i = 4.5) versus Spinacia oleracea RpiA, and hence appears as a promising lead for the design of potent species-specific inhibitors of the bacterial enzyme. © 2005 Elsevier Ltd. All rights reserved

Publicerad i

Tetrahedron Letters
2005, Volym: 46, nummer: 21, sidor: 3691-3694
Utgivare: PERGAMON-ELSEVIER SCIENCE LTD

SLU författare

• Mowbray, Sherry

  • Institutionen för molekylär biovetenskap, Sveriges lantbruksuniversitet
    

UKÄ forskningsämne

Livsmedelsvetenskap


Publikationens identifierare

DOI: https://doi.org/10.1016/j.tetlet.2005.03.151

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/8422