Broberg, Anders
- Department of Molecular Sciences, Swedish University of Agricultural Sciences
Abstract
Bioassay-guided fractionation of culture supernatants of the actinomycete Kutzneria sp. 744 resulted in the isolation of four new depsipeptides (1-4). Structure analysis revealed the general structure: cyclo[2-(I-methylcyclopropyl)-D-glycine-(2S,3aR,8aS)-6,7-dichloro-3a-hydroxy-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole-2-carboxylic acid-3-hydroxy-D-glutamic acid-o-methyl-L-serine-L-piperazie acid-(S)-2-hydroxy-3,3-dimethylbutanoic acid]. The 3-hydroxy-D-glutamic acid was present as its threo-isomer in 1 and 2 and as its erythro-isomer in 3 and 4. The piperazic acid was modified to its (R)-4-chloro analogue in 2 and to its C-5/N unsaturated analogue in 4. Compounds 1-4 displayed moderate spore germination inhibiting activity against several common root-rotting fungi
Published in
Journal of Natural Products
2006, volume: 69, number: 1, pages: 97-102
Publisher: AMER CHEMICAL SOC
SLU Authors
Vasaitis, Rimvydas
- Department of Forest Mycology and Plant Pathology, Swedish University of Agricultural Sciences
- Department of Forest Mycology and Plant Pathology, Swedish University of Agricultural Sciences
Menkis, Audrius
- Department of Forest Mycology and Plant Pathology, Swedish University of Agricultural Sciences
- Department of Forest Mycology and Plant Pathology, Swedish University of Agricultural Sciences
UKÄ Subject classification
Environmental Sciences and Nature Conservation
Publication identifier
- DOI: https://doi.org/10.1021/np050378g
Permanent link to this page (URI)
https://res.slu.se/id/publ/8593