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Research article - Peer-reviewed, 2006

Kutznerides 1-4, depsipeptides from the actinomycete Kutzneria sp 744 inhabiting mycorrhizal roots of Picea abies seedlings

Broberg A, Menkis A, Vasiliauskas R

Abstract

Bioassay-guided fractionation of culture supernatants of the actinomycete Kutzneria sp. 744 resulted in the isolation of four new depsipeptides (1-4). Structure analysis revealed the general structure: cyclo[2-(I-methylcyclopropyl)-D-glycine-(2S,3aR,8aS)-6,7-dichloro-3a-hydroxy-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole-2-carboxylic acid-3-hydroxy-D-glutamic acid-o-methyl-L-serine-L-piperazie acid-(S)-2-hydroxy-3,3-dimethylbutanoic acid]. The 3-hydroxy-D-glutamic acid was present as its threo-isomer in 1 and 2 and as its erythro-isomer in 3 and 4. The piperazic acid was modified to its (R)-4-chloro analogue in 2 and to its C-5/N unsaturated analogue in 4. Compounds 1-4 displayed moderate spore germination inhibiting activity against several common root-rotting fungi

Published in

Journal of Natural Products
2006, volume: 69, number: 1, pages: 97-102
Publisher: AMER CHEMICAL SOC

Authors' information

Swedish University of Agricultural Sciences, Department of Chemistry
Swedish University of Agricultural Sciences, Department of Forest Mycology and Pathology
Swedish University of Agricultural Sciences, Department of Forest Mycology and Pathology

UKÄ Subject classification

Environmental Sciences related to Agriculture and Land-use

Publication Identifiers

DOI: https://doi.org/10.1021/np050378g

URI (permanent link to this page)

https://res.slu.se/id/publ/8593