The leukemia inhibitory factor receptor gene is not involved in the etiology of pituitary dwarfism in German shepherd dogs

Hanson, J. M.; Mol, J. A.; Leegwater, P. A. J.; Kooistra, H. S.; Meij, B. P.

doi:10.1016/j.rvsc.2006.03.001

Research article2006Peer reviewed

The leukemia inhibitory factor receptor gene is not involved in the etiology of pituitary dwarfism in German shepherd dogs

Hanson, J. M.; Mol, J. A.; Leegwater, P. A. J.; Kooistra, H. S.; Meij, B. P.

Abstract

Pituitary dwarfism in German shepherd dogs is characterized by combined pituitary hormone deficiency (CPHD) and intrapituitary cyst formation. Activation of the leukemia inhibitory factor (LIF)-LIF receptor (LIFR) signal transduction pathway results in a similar phenotype in (transgenic) mice. We therefore assessed the role of the LIFR in the etiology of pituitary dwarfism in German shepherd dogs. A polymorphic microsatellite marker (UULIFR) was used to analyze the segregation of the LIFR gene in 22 German shepherd dogs from 4 pedigrees, each including one dwarf. There was no allelic association between UULIFR and the dwarfism phenotype. Based on our findings LIFR was excluded as a candidate gene for CPHD. (c) 2006 Elsevier Ltd. All rights reserved.

Keywords

congenital growth hormone deficiency; canine

Published in

Research in Veterinary Science
2006, Volume: 81, number: 3, pages: 316-320

UKÄ Subject classification

Clinical Science

Publication identifier

DOI: https://doi.org/10.1016/j.rvsc.2006.03.001

Permanent link to this page (URI)

https://res.slu.se/id/publ/86238