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Research article - Peer-reviewed, 2006

The leukemia inhibitory factor receptor gene is not involved in the etiology of pituitary dwarfism in German shepherd dogs

Hanson, J. M.; Mol, J. A.; Leegwater, P. A. J.; Kooistra, H. S.; Meij, B. P.


Pituitary dwarfism in German shepherd dogs is characterized by combined pituitary hormone deficiency (CPHD) and intrapituitary cyst formation. Activation of the leukemia inhibitory factor (LIF)-LIF receptor (LIFR) signal transduction pathway results in a similar phenotype in (transgenic) mice. We therefore assessed the role of the LIFR in the etiology of pituitary dwarfism in German shepherd dogs. A polymorphic microsatellite marker (UULIFR) was used to analyze the segregation of the LIFR gene in 22 German shepherd dogs from 4 pedigrees, each including one dwarf. There was no allelic association between UULIFR and the dwarfism phenotype. Based on our findings LIFR was excluded as a candidate gene for CPHD. (c) 2006 Elsevier Ltd. All rights reserved.


congenital growth hormone deficiency; canine

Published in

Research in Veterinary Science
2006, Volume: 81, number: 3, pages: 316-320

    UKÄ Subject classification

    Clinical Science

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