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Research article - Peer-reviewed, 2006

Antimicrobial dialkylresorcinols from Pseudomonas sp Ki19

Pohanka A, Levenfors J, Broberg A


Four dialkylresorcinols (1-4) were isolated from a liquid culture of Pseudomonas sp. Ki19. Compounds 1 and 2, 2-butyl-5-propylresorcinol and 2-hexyl-5-methylresorcinol, respectively, have not previously been isolated from biological sources, whereas 3 and 4, 2-hexyl-5-propylresorcinol (DB-2073) and 2-hexyl-5-pentylresorcinol ( resorstatin), both have been found in biological systems. The compounds inhibited Staphyllococcus aureus at concentrations <= 10 mu g/mL as well as the fungi Aspergillus fumigatus and Fusarium culmorum at 50 mu g/mL. The formation of possible antimicrobial quinone oxidation products was investigated under bioassay conditions, and they were not found to be responsible for the main antimicrobial activity

Published in

Journal of Natural Products
2006, Volume: 69, number: 4, pages: 654-657