Haubro Andersen, Pia
- Department of Clinical Sciences, Swedish University of Agricultural Sciences
Abstract
Objective To compare the analgesic effect of intra-articular (IA) and intravenous (IV) morphine in horses with experimentally induced synovitis.Animals Eight adult horses.Study design Randomized, observer blinded, double dummy trial with sequential crossover design.Methods Radiocarpal synovitis was induced by IA injection of lipopolysaccharide on two occasions separated by a 3-week washout period. In one study period horses received treatment IA; morphine IA (0.05 mg kg(-1)) plus saline IV and in the other study period they received treatment IV; saline IA plus morphine IV ( 0.05 mg kg) 1). Lameness and pain were evaluated repeatedly by two observers throughout each of the two 168-hour study periods. Pain was evaluated by use of a visual analogue scale of pain intensity ( VAS) and a composite measure pain scale ( CMPS). Comparison of treatments was performed by analysis of variance with repeated measurements. Significance level was set to p
Keywords
equine; intra-articular morphine; lameness; lipopolysaccharide; pain-scoring; synovitis
Published in
Veterinary Anaesthesia and Analgesia
2010, volume: 37, number: 2, pages: 171-185
Publisher: WILEY-BLACKWELL PUBLISHING, INC
SLU Authors
UKÄ Subject classification
Clinical Science
Publication identifier
- DOI: https://doi.org/10.1111/j.1467-2995.2009.00521.x
Permanent link to this page (URI)
https://res.slu.se/id/publ/87218