Abstract

The joint cavity constitutes a discrete anatomical compartment that allows for local drug action after intra-articular injection. Drug delivery systems providing local prolonged drug action are warranted in the management of postoperative pain and not least arthritic disorders such as osteoarthritis. The present review surveys various themes related to the accomplishment of the correct timing of the events leading to optimal drug action in the joint space over a desired time period. This includes a brief account on (patho)physiological conditions and novel potential drug targets (and their location within the synovial space). Particular emphasis is paid to W the potential feasibility of various depot formulation principles for the intra-articular route of administration including their manufacture, drug release characteristics and in vivo fate, and (ii) how release, mass transfer and equilibrium processes may affect the intra-articular residence time and concentration of the active species at the ultimate receptor site. (C) 2008 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 97:4622-4654, 2008

Keywords

controlled release/delivery; distribution; drug delivery system; formulation; intra-articular; osteoarthritis; parenteral depot formulation; postoperative pain; rheumatoid arthritis; targeted drug delivery

Published in

Journal of Pharmaceutical Sciences
2008, Volume: 97, number: 11, pages: 4622-4654

UKÄ Subject classification

Pharmacology and Toxicology


Publication identifier

DOI: https://doi.org/10.1002/jps.21346

Permanent link to this page (URI)

https://res.slu.se/id/publ/87227