Hofius, Daniel
- University of Copenhagen
Abstract
Ancient autophagy pathways are emerging as key defense modules in host eukaryotic cells against microbial pathogens. Apart from actively eliminating intracellular intruders, autophagy is also responsible for cell survival, for example by reducing the deleterious effects of endoplasmic reticulum stress. At the same time, autophagy can contribute to cellular suicide. The concurrent engagement of autophagy in these processes during infection may sometimes mask its contribution to differing pro-survival and pro-death decisions. The importance of autophagy in innate immunity in mammals is well documented, but how autophagy contributes to plant innate immunity and cell death is not that clear. A few research reports have appeared recently to shed light on the roles of autophagy in plant-pathogen interactions and in disease-associated host cell death. We present a first attempt to reconcile the results of this research. Cell Death and Differentiation (2011) 18, 1257-1262; doi:10.1038/cdd.2011.43; published online 29 April 2011
Keywords
autophagy; ATG genes; innate immunity; plants
Published in
Cell Death and Differentiation
2011, volume: 18, number: 8, pages: 1257-1262
SLU Authors
UKÄ Subject classification
Cell Biology
Botany
Publication identifier
- DOI: https://doi.org/10.1038/cdd.2011.43
Permanent link to this page (URI)
https://res.slu.se/id/publ/87379