A family of putative transcription termination factors shared amongst metazoans and plants

Abstract

The human mitochondrial transcription termination factor (mTERF) is involved in the regulation of transcription of the mitochondrial genome. Similarity searches and phylogenetic analysis demonstrate that mTERF is a member of large and complex protein family (the MTERF family) shared amongst metazoans and plants. Interestingly, we identify three novel MTERF genes in vertebrates, which all encode proteins with predicted mitochondrial localization. Members of the MTERF family have so far not been detected in fungi, supporting the notion that mitochondrial transcription regulation may have evolved separately in yeast and animal cells.

Keywords

mTERF; transcription; mitochondrion; termination

Published in

Current Genetics
2005, volume: 48, number: 4, pages: 265-269
Publisher: SPRINGER

SLU Authors

• Linder, Tomas

  • Karolinska Institute

UKÄ Subject classification

Bioinformatics and Computational Biology (Methods development to be 10203)

Publication identifier

• DOI: https://doi.org/10.1007/s00294-005-0022-5

Permanent link to this page (URI)

https://res.slu.se/id/publ/90880