Correspondence on Lovell et al.: identification of chicken genes previously assumed to be evolutionarily lost

Bornelov, Susanne; Seroussi, Eyal; Yosefi, Sara; Pendavis, Ken; Burgess, Shane C.; Grabherr, Manfred; Friedman-Einat, Miriam; Andersson, Leif

doi:10.1186/s13059-017-1231-1

Research article2017Peer reviewedOpen access

Correspondence on Lovell et al.: identification of chicken genes previously assumed to be evolutionarily lost

Bornelov, Susanne; Seroussi, Eyal; Yosefi, Sara; Pendavis, Ken; Burgess, Shane C.; Grabherr, Manfred; Friedman-Einat, Miriam; Andersson, Leif

Abstract

Through RNA-Seq analyses, we identified 137 genes that are missing in chicken, including the long-sought-after nephrin and tumor necrosis factor genes. These genes tended to cluster in GC-rich regions that have poor coverage in genome sequence databases. Hence, the occurrence of syntenic groups of vertebrate genes that have not been observed in Aves does not prove the evolutionary loss of such genes.

Published in

Genome Biology
2017, Volume: 18, article number: 112
Publisher: BIOMED CENTRAL LTD

SLU Authors

Andersson, Leif
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
- Texas A&M University
- Uppsala University

UKÄ Subject classification

Genetics and Breeding

Publication identifier

DOI: https://doi.org/10.1186/s13059-017-1231-1

Permanent link to this page (URI)

https://res.slu.se/id/publ/91110