Gabrielsson, Johan
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
Abstract
Radiotherapy is one of the major therapy forms in oncology, and combination therapies involving radiation and chemical compounds can yield highly effective tumor eradication. In this paper, we develop a tumor growth inhibition model for combination therapy with radiation and radiosensitizing agents. Moreover, we extend previous analyses of drug combinations by introducing the tumor static exposure (TSE) curve. The TSE curve for radiation and radiosensitizer visualizes exposure combinations sufficient for tumor regression. The model and TSE analysis are then tested on xenograft data. The calibrated model indicates that the highest dose of combination therapy increases the time until tumor regrowth 10‐fold. The TSE curve shows that with an average radiosensitizer concentration of urn:x-wiley:21638306:media:psp412268:psp412268-math-0002 the radiation dose can be decreased from urn:x-wiley:21638306:media:psp412268:psp412268-math-0003 to urn:x-wiley:21638306:media:psp412268:psp412268-math-0004. Finally, we successfully predict the effect of a clinically relevant treatment schedule, which contributes to validating both the model and the TSE concept.
Published in
CPT: Pharmacometrics & Systems Pharmacology
2018, volume: 7, number: 1, pages: 51-58
SLU Authors
UKÄ Subject classification
Pharmacology and Toxicology
Publication identifier
- DOI: https://doi.org/10.1002/psp4.12268
Permanent link to this page (URI)
https://res.slu.se/id/publ/91974