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Research article2018Peer reviewedOpen access

Normal values for calprotectin in stool samples of infants from the population-based longitudinal born into life study

Peura, Sari; Fall, Tove; Almqvist, Catarina; Andolf, Ellika; Hedman, Anna; Pershagen, Goran; Helmersson-Karlqvist, Johanna; Larsson, Anders

Abstract

Faecal calprotectin is a protein used as a diagnostic marker for inflammatory bowel diseases. We determined upper limits for normal calprotectin values for neonatal, 6, 12 and 24months old children using a turbidimetric immunoassay in a cohort of Swedish children. The advantage of the method is that opposite to previously used enzyme-linked immunosorbent assay (ELISA) method, it enables measuring single samples, and thus, shortens the analysis time significantly. There were 72 samples (41.7% female) collected neonatally, 63 samples (34.9% female) at 6months, 60 samples (40.0% female) at 12months and 51 samples (43.1% female) at 24months. The upper limits for normal values were 233, 615, 136 and 57 mu g mg(-1) for infants aged 0, 6, 12 and 24months, respectively.

Keywords

Calprotectin; turbidimetric immunoassay; normal values; inflammatory bowel disease; abdominal pain

Published in

Scandinavian Journal of Clinical and Laboratory Investigation
2018, Volume: 78, number: 1-2, pages: 120-124
Publisher: TAYLOR & FRANCIS LTD

      SLU Authors

      UKÄ Subject classification

      Rheumatology and Autoimmunity

      Publication identifier

      DOI: https://doi.org/10.1080/00365513.2017.1420216

      Permanent link to this page (URI)

      https://res.slu.se/id/publ/94066