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Research article2017Peer reviewedOpen access

Cholesterol uptake in the mouse aorta increases during Chlamydia pneumoniae infection

Edvinsson, Marie; Tallkvist, Jonas; Nystrom-Rosander, Christina; Ilback, Nils-Gunnar

Abstract

Chlamydia pneumoniae has been suggested as a stimulator of the atherosclerotic process. Mice fed a normal diet were infected intranasally with C. pneumoniae and given one intraperitoneal injection of C-14-cholesterol tracer per day for 12 days. Bacteria were demonstrated in the aorta in the early phase of infection and in lungs and liver throughout the study period of 20 days. C-14-cholesterol was not affected in the heart but increased in the blood, liver and aorta on day 4 when the infection was clinically most severe. Furthermore, on day 20 C-14-cholesterol tended to be increased in the aorta. Accordingly, copper-and zinc levels and expressions of the infection biomarkers Cxcl2 and Ifng increased in the liver on day 4 with a tendency of increased of copper, zinc and Ifng on day 20. In mice where bacteria could be cultivated from the lungs, expressions of cholesterol transporters Abca1 and Idol were both increased in the liver on day 4. The increased levels of C-14-cholesterol in blood and aorta together with increased Abca1 and Idol in the liver during C. pneumoniae infection in mice fed a normal diet suggest that this pathogen may have a role in the initiation of the atherosclerotic process.

Keywords

Chlamydia pneumoniae; atherosclerosis; cholesterol; Idol; Abca1; Cxcl2; interferon gamma; mouse; copper; zinc

Published in

Pathogens and Disease
2017, Volume: 75, number: 1, article number: ftx004
Publisher: OXFORD UNIV PRESS

    UKÄ Subject classification

    Immunology in the medical area

    Publication identifier

    DOI: https://doi.org/10.1093/femspd/ftx004

    Permanent link to this page (URI)

    https://res.slu.se/id/publ/94087