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Abstract

Background: Epidemiologic evidence on the association of a healthy Nordic diet and future type 2 diabetes (T2D) is limited. Exploring metabolites as biomarkers of healthy Nordic dietary patterns may facilitate investigation of associations between such patterns and T2D.Objectives: We aimed to identify metabolites related to a priori-defined healthy Nordic dietary indexes, the Baltic Sea Diet Score (BSDS) and Healthy Nordic Food Index (HNFI), and evaluate associations with the T2D risk in a case-control study nested in a Swedish population-based prospective cohort.Design: Plasma samples from 421 case-control pairs at baseline and samples from a subset of 151 healthy controls at a 10-y follow-up were analyzed with the use of untargeted liquid chromatography-mass spectrometry metabolomics. Index-related metabolites were identified through the use of random forest modelling followed by partial correlation analysis adjustment for lifestyle confounders. Metabolite patterns were derived via principal component analysis (PCA). ORs of T2D were estimated via conditional logistic regression. Reproducibility of metabolites was assessed by intraclass correlation (ICC) in healthy controls. Associations were also assessed for 10 metabolites previously identified as linking a healthy Nordic diet with T2D.Results: In total, 31 metabolites were associated with BSDS and/or HNFI (-0.19

Keywords

type 2 diabetes; healthy Nordic dietary pattern; HNFI; BSDS; metabolomics; biomarker; nested case-control study

Published in

American Journal of Clinical Nutrition
2018, volume: 108, number: 3, pages: 564-575
Publisher: OXFORD UNIV PRESS

SLU Authors

Global goals (SDG)

SDG3 Good health and well-being

UKÄ Subject classification

Endocrinology and Diabetes
Nutrition and Dietetics

Publication identifier

  • DOI: https://doi.org/10.1093/ajcn/nqy145

Permanent link to this page (URI)

https://res.slu.se/id/publ/96572