Daily intake of phthalates, MEHP, and DINCH by ingestion and inhalation

Weiss, Jana M.; Gustafsson, Asa; Gerde, Per; Bergman, Ake; Lindh, Christian H.; Krais, Annette M.

doi:10.1016/j.chemosphere.2018.05.094

Research article2018Peer reviewedOpen access

Daily intake of phthalates, MEHP, and DINCH by ingestion and inhalation

Weiss, Jana M.; Gustafsson, Asa; Gerde, Per; Bergman, Ake; Lindh, Christian H.; Krais, Annette M.

Abstract

Phthalate esters, suspected endocrine disrupting chemicals, are used in a wide range of applications. Because phthalate esters are not covalently bound, they can easily leach into the indoor environment and associate to dust particles. Thus, exposure may occur through inhalation, ingestion, or contact with the skin. However, it is unclear to what degree indoor dust contributes to the daily intake of phthalate esters.This study investigates household dust as an exposure pathway for seven phthalate esters, the monoester MEHP, and the plasticizer DINCH. Household dust collected from children's sleeping rooms and from living rooms were analysed using gas and liquid chromatography tandem mass spectrometry. To compare two exposure pathways, different dust particle sizes were generated: a respirable fraction (<5 mu m) and an ingested particle fraction in the anticipated size range of skin adherence (<75 mu m). Modelling of dust inhalation and ingestion showed that the daily intake of dust-bound phthalate esters was likely to be 2 times (inhalation) to 12 times (ingestion) higher for 21-month-old children than for adults. These children's daily uptake of phthalate esters was 40-140 times higher through ingestion than inhalation. Furthermore, dust may be an exposure pathway for phthalate esters as well as for MEHP. Therefore, phthalate monoesters could be environmental contaminants of their own and need to be considered in health risk assessments. (C) 2018 Elsevier Ltd. All rights reserved.

Keywords

Phthalate esters; Phthalate monoesters; Household dust; Pollution particles; Indoor pollution; Indoor environment

Published in

Chemosphere
2018, volume: 208, pages: 40-49
Publisher: PERGAMON-ELSEVIER SCIENCE LTD

SLU Authors

Weiss, Jana
- Department of Aquatic Sciences and Assessment, Swedish University of Agricultural Sciences
- Stockholm University

Global goals (SDG)

SDG3 Good health and well-being

UKÄ Subject classification

Environmental Health and Occupational Health

Publication identifier

DOI: https://doi.org/10.1016/j.chemosphere.2018.05.094

Permanent link to this page (URI)

https://res.slu.se/id/publ/96596