Jagarlamudi, Kiran Kumar
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
Review article2018Peer reviewedOpen access
Jagarlamudi, Kiran Kumar; Shaw, Martin
Thymidine kinase 1 (TK1) is a key enzyme in DNA precursor synthesis. It is upregulated during the S phase of the cell cycle and its presence in cells is an indicator of active cell proliferation. In studies since the 1980s, TK1 has been shown as a clinically valuable biomarker for the management of hematological malignancies. However, TK1 activity assays may underestimate serum TK1 in subjects with solid tumors limiting its sensitivity. The development of TK1 immunoassays has made the assay of TK1 more widely available and increased its applicability to solid tumor diseases. This paper will review TK1 as a tumor biomarker with emphasis on recent studies and technologies plus highlight its potential in drug discovery and as a therapeutic target.
anti-TK1 antibodies; biomarker; breast cancer; cell culture; complementary biomarker; Hodgkin; leukemia; lymphoma; proliferation; prostate cancer; solid tumors; TK1; TK 210 ELISA; translational biomarker
Biomarkers in Medicine
2018, Volume: 12, number: 9, pages: 1035-1048 Publisher: FUTURE MEDICINE LTD
SDG3 Good health and well-being
Medical Bioscience
DOI: https://doi.org/10.2217/bmm-2018-0157
https://res.slu.se/id/publ/96704