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Research article2018Peer reviewed

Low-dose exposure to Bisphenol A during development has limited effects on male reproduction in midpubertal and aging Fischer 344 rats

Sporndly-Nees, Ellinor; Boberg, Julie; Ekstedt, Elisabeth; Holm, Lena; Fakhrzadeh, Azadeh; Dunder, Linda; Kushnir, Mark M.; Lejonklou, Margareta H.; Lind, P. Monica


Low doses of Bisphenol A (BPA) during development may affect reproduction. In this study, Fischer 344 rats were exposed to 0.5 or 50 mu g BPA/kg bw/day via drinking water from gestational day 3.5 to postnatal day 22. Anogenital distance, organ weight, histopathology of reproductive organs, hormone analysis and sperm morphology were evaluated in male offspring. In this study no major effects of BPA on male reproduction in mid-pubertal (postnatal day 35) or adult (12-month-old) rats were revealed, apart from a higher prevalence of mild inflammatory cell infiltrate in cauda epididymis in adult rats exposed to 50 mu g BPA/kg bw/day. No BPA-related effects on sexual development were seen but care should be taken when evaluating histopathology in midpuberty testis due to large morphological variation. Results from the present study show no major signs of altered male reproduction in rats exposed to low doses of BPA during gestation and lactation.


Bisphenol A; Developmental exposure; Low dose; Male reproduction; Puberty; Aging; Histopathology; Endocrine disrupting chemical

Published in

Reproductive Toxicology
2018, Volume: 81, pages: 196-206