Research article - Peer-reviewed, 2018
Low-dose exposure to Bisphenol A during development has limited effects on male reproduction in midpubertal and aging Fischer 344 rats
Sporndly-Nees, Ellinor; Boberg, Julie; Ekstedt, Elisabeth; Holm, Lena; Fakhrzadeh, Azadeh; Dunder, Linda; Kushnir, Mark M.; Lejonklou, Margareta H.; Lind, P. MonicaAbstract
Low doses of Bisphenol A (BPA) during development may affect reproduction. In this study, Fischer 344 rats were exposed to 0.5 or 50 mu g BPA/kg bw/day via drinking water from gestational day 3.5 to postnatal day 22. Anogenital distance, organ weight, histopathology of reproductive organs, hormone analysis and sperm morphology were evaluated in male offspring. In this study no major effects of BPA on male reproduction in mid-pubertal (postnatal day 35) or adult (12-month-old) rats were revealed, apart from a higher prevalence of mild inflammatory cell infiltrate in cauda epididymis in adult rats exposed to 50 mu g BPA/kg bw/day. No BPA-related effects on sexual development were seen but care should be taken when evaluating histopathology in midpuberty testis due to large morphological variation. Results from the present study show no major signs of altered male reproduction in rats exposed to low doses of BPA during gestation and lactation.Keywords
Bisphenol A; Developmental exposure; Low dose; Male reproduction; Puberty; Aging; Histopathology; Endocrine disrupting chemicalPublished in
Reproductive Toxicology2018, volume: 81, pages: 196-206
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Authors' information
Swedish University of Agricultural Sciences, Department of Anatomy, Physiology and Biochemistry (AFB)
Broberg, Julie
Technical University of Denmark (DTU)
Ekstedt, Elisabeth
Swedish University of Agricultural Sciences, Department of Anatomy, Physiology and Biochemistry (AFB)
Swedish University of Agricultural Sciences, Department of Anatomy, Physiology and Biochemistry (AFB)
Fakhrzadeh, Azadeh
Iranian Research Institute for Information Science and Technology (IRANDOC)
Dunder, Linda
Uppsala University
Kushnir, Mark M.
University of Utah
Lejonklou, Margareta H.
Uppsala University
Lind, P. Monica
Uppsala University
UKÄ Subject classification
Medical Bioscience
Publication Identifiers
DOI: https://doi.org/10.1016/j.reprotox.2018.08.007
URI (permanent link to this page)
https://res.slu.se/id/publ/97059