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Research article - Peer-reviewed, 2000

Pharmacokinetics and pharmacodynamics of terbutaline in healthy horses

Torneke, MK; Ingvast-Larsson, JC; Johansson, JM; Appelgren, LE

Abstract

Objective-To determine pharmacokinetics of terbutaline in healthy horses and to relate serum terbutaline concentrations with the drug's pharmacodynamic effects.Animals-6 healthy horses.Procedure-Horses were given terbutaline IV (10 mu g/kg of body weight) and, 1 week later, PO (100 mu g/kg). Responses to drug administration (eg, heart rate and serum lactate concentration) were measured. Serum terbutaline concentration was measured by means of gas chromatography with mass spectrometry. Protein binding was determined in vitro.Results-Following IV administration, median maximum serum terbutaline concentration and mean residence time were 9.3 ng/ml and 30 minutes, respectively. Bioavailability following oral administration was < 1%. All horses developed sweating, trembling, excitement, and tachycardia during IV infusion. The 2 horses with the highest serum terbutaline concentrations developed severe tachycardia and CNS stimulation; 30 minutes after the IV infusion was completed, they were hyperventilating and lethargic. Heart rate and serum lactate concentration increased as serum terbutaline concentration increased.Conclusions and Clinical Relevance-Results indicated that terbutaline is rapidly cleared from the bloodstream following IV administration to horses, suggesting that continuous IV infusion would be needed to maintain therapeutic serum concentrations. Oral administration of terbutaline to horses is not practical because of the low bioavailability.

Published in

American Journal of Veterinary Research
2000, Volume: 61, number: 7, pages: 761-765
Publisher: AMER VETERINARY MEDICAL ASSOC

      SLU Authors

    • Törneke, Karolina

      • Department of Pharmacology and Toxicology, Swedish University of Agricultural Sciences
      • Ingvast Larsson, Carina

        • Department of Pharmacology and Toxicology, Swedish University of Agricultural Sciences
        • Appelgren, Lars-Erik

          • Department of Pharmacology and Toxicology, Swedish University of Agricultural Sciences

        UKÄ Subject classification

        Pathobiology

        Publication identifier

        DOI: https://doi.org/10.2460/ajvr.2000.61.761

        Permanent link to this page (URI)

        https://res.slu.se/id/publ/97417