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Research article - Peer-reviewed, 1992

Distribution studies of theophylline: microdialysis in rat and horse and whole body autoradiography in rat

INGVASTLARSSON, C; APPELGREN, LE; NYMAN, G

Abstract

After intravenous administration of theophylline, microdialysis has been used for studying the non protein bound theophylline concentration in blood and in lung tissue in the rat as well as in two horses. The distribution pattern of C-14-theophylline in the rat was also investigated. When the distribution of theophylline was completed the time course of free drug in the interstitial fluid in lung tissue was in good agreement with the total concentration-time profile in plasma in both species. In the rat the free concentration of theophylline in the lung was slightly lower than the free concentration in the blood from 40 to 300 min. The in vivo protein binding in blood was 48.8 +/- 6.2% in the rats (n = 9) and 8-25% in the horses (n = 2). The whole body autoradiography study in rat showed that the concentration of radioactivity in the lung followed the blood concentration very closely up to 24 h after injection. The effect of theophylline in the lung can be assumed to be related to the plasma concentration of theophylline, since the concentration-time profile in plasma reflects the time course in the lung.

Published in

Journal of Veterinary Pharmacology and Therapeutics
1992, Volume: 15, number: 4, pages: 386-394
Publisher: BLACKWELL SCIENCE LTD

      SLU Authors

    • Ingvast Larsson, Carina

      • Department of Pharmacology and Toxicology, Swedish University of Agricultural Sciences
      • Appelgren, Lars-Erik

        • Department of Pharmacology and Toxicology, Swedish University of Agricultural Sciences
        • Nyman, Görel

          • Department of Medicine and Surgery, Swedish University of Agricultural Sciences

        UKÄ Subject classification

        Pathobiology

        Publication Identifiers

        DOI: https://doi.org/10.1111/j.1365-2885.1992.tb01030.x

        Permanent link to this page (URI)

        https://res.slu.se/id/publ/97429