Wu, Huaxing
- Department of Molecular Sciences, Swedish University of Agricultural Sciences
Research article - Peer-reviewed, 2018
Evaluation of alkylresorcinols in adipose tissue biopsies as a long-term biomarker of whole-grain wheat and rye intake in free-living Swedish men and women
Wu, Huaxing; Omar, Nor Adila Mhd; Hakansson, Niclas; Wolk, Alicia; Michaelsson, Karl; Landberg, Rikard
Abstract
Objective: Wheat and rye, the most consumed whole grains (WG) in the Nordic countries, contain alkylresorcinols (AR) in their bran. AR concentrations in human adipose tissue might reflect long-term WG rye and wheat intake. We aimed to evaluate AR concentrations in adipose tissue biopsies as a long-term biomarker of WG wheat and rye intake in free-living Swedish men and women.Design: Cross-sectional study. AR concentrations in adipose tissue biopsies were analysed and compared with long-term WG intake assessed by three FFQ (repeated over a period of 14 years in men, 17 years in women) and with plasma AR concentrations.Setting: The Cohort of Swedish Men between 1997 and 2010 and the Swedish Mammography Cohort between 1987 and 2003, Sweden.Subjects: Men (n 149) and women (n 109).Results: Long-term WG rye intake estimated with repeated FFQ correlated (r = 0.31-0.41, P<0.01) with adipose-tissue AR concentrations, while WG wheat intake correlated only weakly (r = 0.17-0.33, P < 0.05). Total AR concentration in adipose tissue was 61 % lower in women than in men at similar energy-adjusted WG wheat and rye intakes, but plasma concentrations were similar. AR concentrations in adipose tissue correlated well with plasma concentrations (r = 0.49-0.81, P < 0.001).Conclusions: AR in adipose tissue reflected long-term WG rye but not WG wheat intake, probably due to poor precision in estimating WG wheat intake by FFQ. AR in adipose tissue appears promising as a biomarker of long-term WG rye intake but should be adjusted for sex.
Keywords
Dietary biomarker; Alkylresordnol; Whole grain; Adipose tissue; Plasma
Published in
Public Health Nutrition
2018, Volume: 21, number: 10, pages: 1933-1942
Publisher: CAMBRIDGE UNIV PRESS
Landberg, Rikard
- Department of Molecular Sciences, Swedish University of Agricultural Sciences
- Chalmers University of Technology
- Karolinska Institute
- Department of Molecular Sciences, Swedish University of Agricultural Sciences
SLU Authors
Sustainable Development Goals
SDG3 Good health and well-being
UKÄ Subject classification
Nutrition and Dietetics
Publication Identifiers
DOI: https://doi.org/10.1017/S1368980018000484
Permanent link to this page (URI)
https://res.slu.se/id/publ/97563