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Review article - Peer-reviewed, 2019

Extracellular vesicles and energy metabolism

Ronquist, K. Goran


Glycolytic enzymes are among the most frequently identified proteins in proteomics of exosomes/extracellular vesicles. This review brings up the possibility that exosomes/extracellular vesicles during their life-time in bodily fluids power important energy-consuming functions by glycolytic conversion of glucose or fructose into ATP. It was seen that prostasomes (exosomes of the prostate) could produce ATP by glycolysis and that the produced ATP quickly was consumed by adjacent prostasomal ATPases. The glycolytic ATP production appeared to be coupled to self-sustaining energy requirements. It will also be discussed how a failure in this machinery (lowered activity of ATPases) with a resultant polluting leakage of extracellular ATP could affect cancer development.


Extracellular vesicles; Prostasomes; Exosomes; Glycolysis; Extracellular ATP; Cancer; Premetastatic niche; Lipid rafts

Published in

Clinica Chimica Acta
2019, volume: 488, pages: 116-121

Authors' information

Swedish University of Agricultural Sciences, Department of Clinical Sciences

Sustainable Development Goals

SDG3 Good health and well-being

UKÄ Subject classification

Cell and Molecular Biology

Publication Identifiers


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