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Review article2019Peer reviewedOpen access

Extracellular vesicles and energy metabolism

Ronquist, K. Goran


Glycolytic enzymes are among the most frequently identified proteins in proteomics of exosomes/extracellular vesicles. This review brings up the possibility that exosomes/extracellular vesicles during their life-time in bodily fluids power important energy-consuming functions by glycolytic conversion of glucose or fructose into ATP. It was seen that prostasomes (exosomes of the prostate) could produce ATP by glycolysis and that the produced ATP quickly was consumed by adjacent prostasomal ATPases. The glycolytic ATP production appeared to be coupled to self-sustaining energy requirements. It will also be discussed how a failure in this machinery (lowered activity of ATPases) with a resultant polluting leakage of extracellular ATP could affect cancer development.


Extracellular vesicles; Prostasomes; Exosomes; Glycolysis; Extracellular ATP; Cancer; Premetastatic niche; Lipid rafts

Published in

Clinica Chimica Acta
2019, Volume: 488, pages: 116-121

    Sustainable Development Goals

    SDG3 Good health and well-being

    UKÄ Subject classification

    Cell and Molecular Biology

    Publication identifier


    Permanent link to this page (URI)