Ronquist, Göran
- Department of Clinical Sciences, Swedish University of Agricultural Sciences
Review article2019Peer reviewedOpen access
Ronquist, K. Goran
Glycolytic enzymes are among the most frequently identified proteins in proteomics of exosomes/extracellular vesicles. This review brings up the possibility that exosomes/extracellular vesicles during their life-time in bodily fluids power important energy-consuming functions by glycolytic conversion of glucose or fructose into ATP. It was seen that prostasomes (exosomes of the prostate) could produce ATP by glycolysis and that the produced ATP quickly was consumed by adjacent prostasomal ATPases. The glycolytic ATP production appeared to be coupled to self-sustaining energy requirements. It will also be discussed how a failure in this machinery (lowered activity of ATPases) with a resultant polluting leakage of extracellular ATP could affect cancer development.
Extracellular vesicles; Prostasomes; Exosomes; Glycolysis; Extracellular ATP; Cancer; Premetastatic niche; Lipid rafts
Clinica Chimica Acta
2019, volume: 488, pages: 116-121
Publisher: ELSEVIER SCIENCE BV
SDG3 Good health and well-being
Cell and Molecular Biology
https://res.slu.se/id/publ/98379