Effect of ACTH (tetracosactide) on steroid hormone levels in the mare Part B: Effect in ovariectomized mares (including estrous behavior)

Abstract

The mare is the only non-primate species known to display estrous signs after ovariectomy and adrenal hormones have been implicated as a possible cause. Moreover, in several species, estradiol seems to have a stimulatory effect on the hypothalamic-pituitary-adrenal axis. The aim of the present study was to compare the effect of ACTH (tetracosactide) on pertinent hormones [cortisol, progesterone, androstenedione, testosterone (intact and ovariectomized mares) and estradiol (ovariectomized mares only)] in intact mares in estrus with the same mares after ovariectomy (n=5). Blood samples were collected hourly from 12:00 until 14:00h the following day (half-hourly between 14:00 and 17:00h) on two occasions, with saline or ACTH treatment at 14:00h (saline treatment day or ACTH treatment day). The mares, both when intact and after ovariectomy, showed a significant increase in all measured hormones, except estradiol (not measured in intact mares), after ACTH treatment, lasting at least 3h post-treatment (P

Published in

Animal Reproduction Science
2006, pages: 1-15

SLU Authors

• Hedberg Alm, Ylva

  • Department of Clinical Sciences, Swedish University of Agricultural Sciences
    

• Dalin, Anne-Marie

  • Department of Clinical Sciences, Swedish University of Agricultural Sciences
    

• Lundeheim, Nils

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Kindahl, Hans

  • Department of Clinical Sciences, Swedish University of Agricultural Sciences
    

UKÄ Subject classification

Animal and Dairy Science
Veterinary Science

Permanent link to this page (URI)

https://res.slu.se/id/publ/9871