Research article2010Peer reviewed
Asymmetric Synthesis of alpha- and beta-Benzylhydroxy-gamma-butyrolactones
Pinho, Pedro; Pelcman, Mikael; Agback, Tatiana; Samuelsson, Bertil
Abstract
Herein we describe a new asymmetric synthesis of alpha-benzyl-alpha-hydroxy-gamma-butyrolactone, a core building block of new HIV-1 protease inhibitors containing a tertiary alcohol in the transition-state mimic. Immediate access to beta-benzyl-beta-hydroxy-gamma-butyrolactone is also possible from a common intermediate. Both lactones are useful building blocks in their own right.
Keywords
lactones; asymmetric catalysis; epoxidations; oxidations; HIV
Published in
Synlett
2010, number: 1, pages: 131-133
Publisher: GEORG THIEME VERLAG KG
UKÄ Subject classification
Organic Chemistry
Publication identifier
DOI: https://doi.org/10.1055/s-0029-1218529
Permanent link to this page (URI)
https://res.slu.se/id/publ/99464