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Abstract

Contaminated drinking water (DW) is a major source of exposure to per-and polyfluoroalkyl substances (PFAS) at locations around PFAS production/use facilities and military airports. This study aimed to investigate quan-titative relationships between concentrations in DW and serum of nine perfluoroalkyl acids (PFAAs) in Swedish adult populations living near contamination hotspots. Short-chained (PFPeA, PFHxA, PFHpA, and PFBS) and long-chained PFAAs (PFOA, PFNA, PFDA, PFHxS and PFOS) were measured in DW and serum. We matched DW and serum concentrations for a total of 398 subjects living or working in areas receiving contaminated DW and in one non-contaminated area. Thereafter, linear regression analysis with and without adjustments for co-variates was conducted. This enabled to derive (i) serum concentrations at background exposure (CB) from sources other than local DW exposure (i.e. food, dust and textiles) at 0 ng/L DW concentration, (ii) population-mean PFAA serum:water ratios (SWR) and (iii) PFAA concentrations in DW causing observable elevated serum PFAA con-centrations above background variability. Median concentrations of the sum of nine PFAAs ranged between 2.8 and 1790 ng/L in DW and between 7.6 and 96.9 ng/mL in serum. DW concentration was the strongest predictor, resulting in similar unadjusted and adjusted regression coefficients. Mean CB ranged from

Keywords

PFAS; Human biomonitoring; Tap water; Bioaccumulation; Toxicokinetics; Risk assessment

Published in

Environmental Research
2023, volume: 219, article number: 115024
Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE

SLU Authors

Global goals (SDG)

SDG6 Clean water and sanitation

UKÄ Subject classification

Environmental Health and Occupational Health

Publication identifier

  • DOI: https://doi.org/10.1016/j.envres.2022.115024

Permanent link to this page (URI)

https://res.slu.se/id/publ/121160