Abstract

Six different furanocoumarins were isolated from the aerial parts of Ducrosia anethifolia and tested in vitro for plant cell elongation in etiolated wheat coleoptile. They were also tested for their ability to control three different weeds: ribwort plantain, annual ryegrass, and common purslane. These compounds exhibited strong inhibition of plant cell elongation. In the case of (+)-heraclenin, the IC50 was lower than 20 mu M, indicating a better inhibition than the positive control Logran (R). Computational experiments for docking and molecular dynamics revealed for the investigated furanocoumarins bearing an epoxide moiety an improved fitting and stronger interaction with the auxin-like TIR1 ubiquitin ligase. Furthermore, the formed inhibition complex remained also stable during dynamic evaluation. Bidental interaction at the active site, along with an extended hydrogen-bond lifetime, explained the enhanced activity of the epoxides. The in vitro weed bioassay results showed that Plantago lan-ceolata was the most affected weed for germination, root, and shoot development. In addition, (+)-heraclenin displayed better inhibition values than positive control even at 300 mu M concentration.

Keywords

Weed control; Allelopathy; Bioherbicide; Plantago lanceolata; Lolium rigidum; Portulaca oleracea; Molecular dynamics; Natural product; Furocoumarin

Published in

Phytochemistry
2023, Volume: 215, article number: 113838
Publisher: PERGAMON-ELSEVIER SCIENCE LTD

SLU Authors

• Mottaghipisheh, Javad

  • Department of Aquatic Sciences and Assessment, Swedish University of Agricultural Sciences
    
  • University of Innsbruck
  • University of Szeged

Associated SLU-program

SLU Plant Protection Network


UKÄ Subject classification

Agricultural Science


Publication identifier

DOI: https://doi.org/10.1016/j.phytochem.2023.113838

Permanent link to this page (URI)

https://res.slu.se/id/publ/126564