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Research article2004Peer reviewed

Effect of fluoropyrimidines on the growth of Ureaplasma urealyticum

Wehelie, Rahma; Eriksson, Staffan; Wang, Liya

Abstract

In the present study, we investigated the effect of fluoropyrimidines on the growth of Ureaplasma urealyticum. Addition of fluoropyrimidines strongly inhibited bacterial growth. Growth inhibition by these analogues could be reversed by addition of either thymidine or deoxyuridine, suggesting inhibition of thymidylate biosynthesis as the mechanism in operation.

Keywords

Ureaplasma; nucleoside analogues; growth inhibition; fluoropyrimidines

Published in

Nucleosides, Nucleotides and Nucleic Acids
2004, Volume: 23, number: 8-9, pages: 1499-1502

      SLU Authors

    • Wehelie, Rahma

      • Department of Molecular Biosciences, Swedish University of Agricultural Sciences

      • Eriksson, Staffan

        • Department of Molecular Biosciences, Swedish University of Agricultural Sciences

        • Wang, Liya

          • Department of Molecular Biosciences, Swedish University of Agricultural Sciences

        UKÄ Subject classification

        Microbiology in the medical area

        Publication identifier

        DOI: https://doi.org/10.1081/NCN-200027714

        Permanent link to this page (URI)

        https://res.slu.se/id/publ/53110