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Research article2012Peer reviewed

Biocompatible titania hydrogels with chemically triggered release of a photosensitive dye

Rychtarikova, Renata; Seisenbaeva, Gulaim A.; Kuncova, Gabriela; Kessler, Vadim G.

Abstract

5,10,15,20-Tetrakis(4-sulfonatophenyl)porphyrin was entrapped into biocompatible hydrogels formed by self-assembling micelles of the titanium dioxide prepared by hydrolysis of titanium ethoxide modified with triethanolamine (TEA). The materials were characterized by their optical and photosensitive properties. The immobilization led to changes of the absorption spectra of the dye and decreased its molar absorption coefficient. The TiO2 matrix did not degrade the entrapped porphyrin upon u.v. irradiation. The formation of TEA-titanium(IV) chelates facilitated a controlled and triggered release of the immobilized dye from the hydrogels in lactate and citrate buffers. The released dye prolonged the sterility of citrate-phosphate buffer and its illumination with visible light inhibited growth of .

Keywords

Sol-gel; Photosterilization; Immobilization; Biocompatible titanium dioxide; Porphyrin

Published in

Journal of Sol-Gel Science and Technology
2012, Volume: 62, number: 3, pages: 370-377
Publisher: SPRINGER