Comparison of developmental toxicity of seven perfluoroalkyl acids to zebrafish embryos

Abstract

The toxicity of individual perfluoroalkyl acids (PFAAs) has been suggested to be determined by the carbon chain length as well as the functional group attached. We tested seven different PFAAs including both sulfonic and carboxylic PFAAs with different chain length to evaluate the developmental toxicity in zebrafish embryos. Generally, the acute toxicity of PFAAs is relatively low to zebrafish embryos. The EC50 values ranged from 1.5 to 2200 mg/L. We observed a relationship between higher toxicity with longer carbon chain. In addition, we also observed a higher toxicity for sulfonic PFAAs than for carboxylic PFAAs. (C) 2013 Elsevier B.V. All rights reserved.

Keywords

Perfluoroalkyl acids; Zebrafish; Embryo; Toxicity

Published in

Environmental toxicology and pharmacology
2013, volume: 36, number: 2, pages: 423-426
Publisher: ELSEVIER SCIENCE BV

SLU Authors

• Ul haq, Mazhar

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Carlsson, Gunnar

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Örn, Stefan

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Norrgren, Leif

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

UKÄ Subject classification

Developmental Biology

Publication identifier

• DOI: https://doi.org/10.1016/j.etap.2013.05.004

Permanent link to this page (URI)

https://res.slu.se/id/publ/53699