Sammanfattning

Sodium meta-arsenite (NaAsO2) has been suggested to play a role both in initiation/progression of prostate cancer and as a future antiprostate cancer drug. We have studied the effects of NaAsO2 on cell proliferation of prostate cancer and noncancer cells, breast cancer cells, and adrenocortical carcinoma cells in vitro. Further, we have investigated the effect of NaAsO2 on the androgen receptor. We report that NaAsO2 alters the cell proliferation of prostate cells, in a hormetic manner, by increasing cell proliferation at low concentrations and decreasing the cell proliferation at high concentrations. No activation of the androgen receptor was detected. We conclude that NaAsO2 is able to increase cell proliferation of prostate cells in vitro at low concentrations, while it decreases cell viability at high concentrations. This novel finding has to be further addressed if NaAsO2 should be developed into an antiprostate cancer drug.

Nyckelord

androgen receptor activation; cell viability; hormetic effects; prostate cancer

Publicerad i

Dose-Response
2019, Volym: 17, nummer: 2, artikelnummer: 1559325819843374
Utgivare: SAGE PUBLICATIONS INC

SLU författare

• Lundqvist, Johan

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    

• Helmersson, Erik

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    

• Oskarsson, Agneta

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    

Globala målen

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UKÄ forskningsämne

Farmakologi och toxikologi


Publikationens identifierare

DOI: https://doi.org/10.1177/1559325819843374

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/100095