Integration of molecular profiles in a longitudinal wellness profiling cohort

Tebani, Abdellah; Gummesson, Anders; Zhong, Wen; Koistinen, Ina Schuppe; Lakshmikanth, Tadepally; Olsson, Lisa M.; Boulund, Fredrik; Neiman, Maja; Stenlund, Hans; Hellstrom, Cecilia; Karlsson, Max J.; Arif, Muhammad; Dodig-Crnkovic, Tea; Mardinoglu, Adil; Lee, Sunjae; Zhang, Cheng; Chen, Yang; Olin, Axel; Mikes, Jaromir; Danielsson, Hanna; von Feilitzen, Kalle; Jansson, Per-Anders; Angeras, Oskar; Huss, Mikael; Kjellqvist, Sanela; Odeberg, Jacob; Edfors, Fredrik; Tremaroli, Valentina; Forsstrom, Bjorn; Schwenk, Jochen M.; Nilsson, Peter; Moritz, Thomas; Backhed, Fredrik; Engstrand, Lars; Brodin, Petter; Bergstrom, Goran; Uhlen, Mathias; Fagerberg, Linn

doi:10.1038/s41467-020-18148-7

Forskningsartikel2020Vetenskapligt granskadÖppen tillgång

Integration of molecular profiles in a longitudinal wellness profiling cohort

Tebani, Abdellah; Gummesson, Anders; Zhong, Wen; Koistinen, Ina Schuppe; Lakshmikanth, Tadepally; Olsson, Lisa M.; Boulund, Fredrik; Neiman, Maja; Stenlund, Hans; Hellstrom, Cecilia; Karlsson, Max J.; Arif, Muhammad; Dodig-Crnkovic, Tea; Mardinoglu, Adil; Lee, Sunjae; Zhang, Cheng; Chen, Yang; Olin, Axel; Mikes, Jaromir; Danielsson, Hanna;
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Sammanfattning

An important aspect of precision medicine is to probe the stability in molecular profiles among healthy individuals over time. Here, we sample a longitudinal wellness cohort with 100 healthy individuals and analyze blood molecular profiles including proteomics, transcriptomics, lipidomics, metabolomics, autoantibodies and immune cell profiling, complemented with gut microbiota composition and routine clinical chemistry. Overall, our results show high variation between individuals across different molecular readouts, while the intra-individual baseline variation is low. The analyses show that each individual has a unique and stable plasma protein profile throughout the study period and that many individuals also show distinct profiles with regards to the other omics datasets, with strong underlying connections between the blood proteome and the clinical chemistry parameters. In conclusion, the results support an individual-based definition of health and show that comprehensive omics profiling in a longitudinal manner is a path forward for precision medicine.

Publicerad i

Nature Communications
2020, Volym: 11, nummer: 1, artikelnummer: 4487
Utgivare: NATURE RESEARCH

SLU författare

Moritz, Thomas
- Institutionen för skoglig genetik och växtfysiologi, Sveriges lantbruksuniversitet

UKÄ forskningsämne

Annan klinisk medicin

Publikationens identifierare

DOI: https://doi.org/10.1038/s41467-020-18148-7

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/110692