Sammanfattning

Hydrogenated vegetable oil (HVO) is a renewable diesel fuel used to replace petroleum diesel. The organic compounds in HVO are poorly characterized; therefore, toxicological properties could be different from petroleum diesel exhaust. The aim of this study was to evaluate the exposure and effective biomarkers in 18 individuals after short-term (3 h) exposure to HVO exhaust and petroleum diesel exhaust fumes. Liquid chromatography tandem mass spectrometry was used to analyze urinary biomarkers. A proximity extension assay was used for the measurement of inflammatory proteins in plasma samples. Short-term (3 h) exposure to HVO exhaust (PM1 similar to 1 mu g/m(3) and similar to 90 mu g/m(3) for vehicles with and without exhaust aftertreatment systems, respectively) did not increase any exposure biomarker, whereas petroleum diesel exhaust (PM1 similar to 300 mu g/m(3)) increased urinary 4-MHA, a biomarker for p-xylene. HVO exhaust from the vehicle without exhaust aftertreatment system increased urinary 4-HNE-MA, a biomarker for lipid peroxidation, from 64 ng/mL urine (before exposure) to 141 ng/mL (24 h after exposure, p < 0.001). There was no differential expression of plasma inflammatory proteins between the HVO exhaust and control exposure group. In conclusion, short-term exposure to low concentrations of HVO exhaust did not increase urinary exposure biomarkers, but caused a slight increase in lipid peroxidation associated with the particle fraction.

Nyckelord

renewable diesel; HVO; exposure studies; biomarkers; aerosol; lipid peroxidation

Publicerad i

International journal of environmental research and public health
2021, Volym: 18, nummer: 12, artikelnummer: 6492
Utgivare: MDPI

SLU författare

• Vogs, Carolina

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    

Globala målen

SDG7 Säkerställa tillgång till ekonomiskt överkomlig, tillförlitlig, hållbar och modern energi för alla


UKÄ forskningsämne

Miljömedicin och yrkesmedicin


Publikationens identifierare

DOI: https://doi.org/10.3390/ijerph18126492

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/112971