Sammanfattning

Prion diseases are a group of neurodegenerative, transmissible, and fatal disorders that affect several animal species. They are characterized by the conformational conversion of the cellular prion protein (PrPC) into the pathological prion protein (PrPSc). In 2016, chronic wasting disease (CWD) gained great importance at European level due to the first disease detection in a wild reindeer (Rangifer tarandus) in Norway. The subsequent intensive CWD surveillance launched in cervids resulted in the detection of CWD in moose (Alces alces), with 11 cases in Norway, 3 in Finland and 4 in Sweden. These moose cases differ considerably from CWD cases in North American and reindeer in Norway, as PrPSc was detectable in the brain but not in lymphoid tissues. These facts suggest the occurrence of a new type of CWD. Here, we show some immunohistochemical features that are clearly different from CWD cases in North American and Norwegian reindeer. Further, the different types of PrPSc deposits found among moose demonstrate strong variations between the cases, supporting the postulation that these cases could carry multiple strains of CWD.

Nyckelord

CWD; moose; prion disease; chronic wasting disease; prions; transmissible spongiform encephalopathy; Norway; Finland; Sweden

Publicerad i

Veterinary Research
2023, Volym: 54, nummer: 1, artikelnummer: 74
Utgivare: BMC

SLU författare

• Gavier Widén, Dolores

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    
  • Sveriges Veterinärmedicinska Anstalt (SVA)

UKÄ forskningsämne

Patobiologi


Publikationens identifierare

DOI: https://doi.org/10.1186/s13567-023-01208-3

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/126557