Sammanfattning

Equine asthma (EA) is a heterogenous, complex disease, with a significant negative impact on horse welfare and performance. EA and human asthma share fundamental similarities, making EA a useful model for studying the disease. One relevant sample type for investigating chronic lung inflammation is bronchoalveolar lavage fluid (BALF), which provides a snapshot of the immune cells present in the alveolar space. To investigate the immune cell landscape of the respiratory tract in horses with mild-to-moderate equine asthma (mEA) and healthy controls, single-cell RNA sequencing was conducted on equine BALF cells. We characterized the major immune cell populations present in equine BALF, as well as subtypes thereof. Interestingly, the most significantly upregulated gene discovered in cases of mEA was FKBP5, a chaperone protein involved in regulating the activity of the glucocorticoid receptor.

Publicerad i

Scientific Reports
2023, Volym: 13, nummer: 1, artikelnummer: 16261
Utgivare: NATURE PORTFOLIO

SLU författare

• Riihimäki, Miia

  • Institutionen för kliniska vetenskaper, Sveriges lantbruksuniversitet
    

• Waern, Ida

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    

• Wernersson, Sara

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    

• Akula, Srinivas

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    

UKÄ forskningsämne

Patobiologi


Publikationens identifierare

DOI: https://doi.org/10.1038/s41598-023-43368-4

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/127227