Sammanfattning

Variance component models are commonly used to detect quantitative trait loci (QTL) in general pedigrees. The variance-covariance structure of the random QTL effect is given by the identity by descent (IBD) between genotypes. Epistatic effects have previously been modeled, both for unlinked and linked loci, as a random effect with a variance-covariance structure given by the Hadamard product between the IBD matrices of the direct QTL effects. In the original papers, the model was given but not derived. Here, we identify the underlying assumptions of this previously proposed model. It assumes that either an unlinked QTL or a fully informative marker (i.e., all marker alleles are unique in the base generation) is located between the loci. We discuss the need of developing a general algorithm to estimate the variance-covariance structure of the random epistatic effect for linked loci.

Publicerad i

Journal of Heredity
2008, Volym: 99, nummer: 4, sidor: 421-425
Utgivare: OXFORD UNIV PRESS INC

UKÄ forskningsämne

Veterinärmedicin
Husdjursvetenskap


Publikationens identifierare

DOI: https://doi.org/10.1093/jhered/esn017

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/19608