Sammanfattning

JNK interacting Protein 1 (JIP-1) is a pivotal scaffolding protein in the JNK signalling pathway. Its expression pattern in murine tissue indicates that JIP-1 has a role in the regulation of different cellular events. By examining the JIP-1 expression in transgenic mice that were heterozygous for a functional insulin-like growth factor II (igf-2) gene, it was possible to show that an abrogated igf-2 expression was followed by a decreased transcription of the JIP-l gene. This pattern was consistent through different litters, which suggests that the up- or down-regulation of JIP-1 may well be part of the intracellular mediation of IGF II induced messages

Publicerad i

In Vivo
2004, Volym: 18, nummer: 5, sidor: 643-647
Utgivare: INT INST ANTICANCER RESEARCH

SLU författare

• Grip, Stefan

  • Gemensamma verksamhetsstödet, Sveriges lantbruksuniversitet
    

• Rising, Anna

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    

• Engström, Wilhelm

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    

UKÄ forskningsämne

Husdjursvetenskap
Veterinärmedicin


Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/21935