Sammanfattning

Accumulating evidence links prefibrillar oligomeric species of the amyloid beta peptide (A beta) to cellular toxicity in Alzheimer's disease, potentially via disruption of biological membranes. Congo red (CR) affects protein aggregation. It is known to self-associate into micelle-like assemblies but still reduces the toxicity of A beta aggregates in cell cultures and model organisms. We show here that CR interacts with A beta(1-40) in a manner similar to that of anionic detergents. Although CR promotes beta sheet formation and peptide aggregation, it may also solubilize toxic protein species, making them less harmful to critical cellular components and thereby reducing amyloid toxicity.

Publicerad i

Biochemistry
2010, Volym: 49, nummer: 7, sidor: 1358-1360

UKÄ forskningsämne

Livsmedelsvetenskap


Publikationens identifierare

DOI: https://doi.org/10.1021/bi902005t

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/34854