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Patent2012

Spider silk proteins and methods for producing spider silk proteins

Johansson, Jan; Hjälm, Göran; Stark, Margareta; Rising, Anna; Grip, Stefan; Engström, Wilhelm; Hedhammar, My

Sammanfattning

The invention provides an isolated major ampullate spidroin protein, which consists of from 150 to 420 amino acid residues and is defined by the formula REP-CT. REP is a repetitive, N-terminally derived protein fragment having from 80 to 300 amino acid residues. CT is a C-terminally derived protein fragment having from 70 to 120 amino acid residues. The invention further provides an isolated fusion protein consisting of a first protein fragment, which is a major ampullate spidroin protein, and a second protein fragment comprising a fusion partner and a cleavage agent recognition site. The first protein fragment is coupled via said cleavage agent recognition site to the fusion partner. The invention also provides a method of producing a major ampullate spidroin protein and polymers thereof.

Publicerad i


Ansökningsnummer: US13/441,118
Patentnummer: US8278416B1
Datum för ansökan: 2012-10-02
Datum för publicering: 2012-10-02