Sammanfattning

In this paper we present a mathematical analysis of the basic model for target mediated drug disposition (TMDD). Assuming high affinity of ligand to target, we give a qualitative characterisation of ligand versus time graphs for different dosing regimes and derive accurate analytic approximations of different phases in the temporal behaviour of the system. These approximations are used to estimate model parameters, give analytical approximations of such quantities as area under the ligand curve and clearance. We formulate conditions under which a suitably chosen Michaelis-Menten model provides a good approximation of the full TMDD-model over a specified time interval.

Publicerad i

Journal of Pharmacokinetics and Pharmacodynamics
2012, Volym: 39, nummer: 5, sidor: 429-51

SLU författare

• Gabrielsson, Johan

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    

UKÄ forskningsämne

Farmakologi och toxikologi
Farmaceutisk vetenskap


Publikationens identifierare

DOI: https://doi.org/10.1007/s10928-012-9260-6

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/42958