Sammanfattning

Spider silk is an interesting biomaterial for medical applications. Recently, a method for production of recombinant spider silk protein (4RepCT) that forms macroscopic fibres in physiological solution was developed. Herein, 4RepCT and Mersilk(TM) (control) fibres were implanted subcutaneously in rats for seven days, without any negative systemic or local reactions. The tissue response, characterised by infiltration of macrophages and multinucleated cells, was similar with both fibres, while only the 4RepCT-fibres supported ingrowth of fibroblasts and newly formed capillaries. This in vivo study indicates that 4RepCT-fibres are well tolerated and could be used for medical applications, e. g., tissue engineering.

Nyckelord

spider silk; recombinant; biocompatibility; in vivo

Publicerad i

Materials
2009, Volym: 2, nummer: 4, sidor: 1908-1922
Utgivare: MDPI AG

SLU författare

• Hedhammar, My

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    

• Nordling, Kerstin

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    

• Johansson, Jan

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    

• Rising, Anna

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    

UKÄ forskningsämne

Medicinska material och protesteknik


Publikationens identifierare

DOI: https://doi.org/10.3390/ma2041908

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/43689