Hillström, Anna
- Institutionen för kliniska vetenskaper, Sveriges lantbruksuniversitet
Forskningsartikel2011Vetenskapligt granskadÖppen tillgång
Hillström, Anna; Tvedten, Harold; Gieger, Urs; Rowe, André
Hereditary phosphofructokinase (PFK) deficiency was diagnosed in two Wachtelhund dogs and suspected in three related Wachtelhund dogs with exercise intolerance, hemolytic anemia, and pigmenturia. Severe, persistent reticulocytosis in light of only mild anemia together with hemoglobinuria after strenuous exercise suggested PFK deficiency. Low erythrocyte PFK activity together with low 2,3-diphosphoglycerate concentrations and a high hemoglobin-oxygen affinity confirmed the diagnosis. The PFK deficiency is due to a single missense mutation in the muscle-type PFK M-PFK gene in English springer and American cocker spaniels, whippets, and mixed-breed dogs; however, these PFK-deficient Wachtelhunds do not have the same PFK mutation.
Journal Of The American Animal Hospital Association
2011, Volym: 47, nummer: 2, sidor: 145-150
Utgivare: AMER ANIMAL HOSPITAL ASSOC
Veterinärmedicin
Husdjursvetenskap
DOI: https://doi.org/10.5326/JAAHA-MS-5619
https://res.slu.se/id/publ/47183