C1q Inhibits Immune Complex-Induced Interferon-alpha Production in Plasmacytoid Dendritic Cells A Novel Link Between C1q Deficiency and Systemic Lupus Erythematosus Pathogenesis

Lood, C; Gullstrand, Birgitta; Truedsson, L; Olin, AI; Alm, Gunnar; Rönnblom, L; Sturfelt, G; Eloranta, ML; Bengtsson, AA

doi:10.1002/art.24852

Forskningsartikel2009Vetenskapligt granskad

C1q Inhibits Immune Complex-Induced Interferon-alpha Production in Plasmacytoid Dendritic Cells A Novel Link Between C1q Deficiency and Systemic Lupus Erythematosus Pathogenesis

Lood, C; Gullstrand, Birgitta; Truedsson, L; Olin, AI; Alm, Gunnar; Rönnblom, L; Sturfelt, G; Eloranta, ML; Bengtsson, AA

Sammanfattning

Conclusion. Our findings contribute to the understanding of why C1q deficiency is such a strong risk factor for SLE and suggest an explanation for the up-regulation of the type I IFN system seen in SLE patients.

Publicerad i

Arthritis and Rheumatism
2009, Volym: 60, nummer: 10, sidor: 3081-3090
Utgivare: WILEY-LISS

SLU författare

Alm, Gunnar
- Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet

UKÄ forskningsämne

Husdjursvetenskap
Veterinärmedicin

Publikationens identifierare

DOI: https://doi.org/10.1002/art.24852

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/49296