Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies

Smolders, Lucas A.; Meij, Björn P.; Onis, David; Riemers, Frank M.; Bergknut, Niklas; Wubbolts, Rickard; Grinwis, Guy C.M.; Houweling, Martin; Groot Koerkamp, Marian J.A.; van Lenen, Dik; Holstege, Frank; Hazewinkel, H.A.W.; Creemers, LB; Penning, LC; Tryfonidou, Marianna A.

doi:10.1186/ar4157

Forskningsartikel2013Vetenskapligt granskadÖppen tillgång

Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies

Smolders, Lucas A.; Meij, Björn P.; Onis, David; Riemers, Frank M.; Bergknut, Niklas; Wubbolts, Rickard; Grinwis, Guy C.M.; Houweling, Martin; Groot Koerkamp, Marian J.A.; van Lenen, Dik; Holstege, Frank; Hazewinkel, H.A.W.; Creemers, LB; Penning, LC; Tryfonidou, Marianna A.

Sammanfattning

Conclusions: Early IVD degeneration involves down-regulation of canonical Wnt signaling and Caveolin-1 expression, which appears to be essential to the physiology and preservation of NCs. Therefore, Caveolin-1 may be regarded an exciting target for developing strategies for IVD regeneration.

Publicerad i

Arthritis Research and Therapy
2013, Volym: 15, nummer: 1
Utgivare: BIOMED CENTRAL LTD

SLU författare

Bergknut, Niklas
- Institutionen för kliniska vetenskaper, Sveriges lantbruksuniversitet

UKÄ forskningsämne

Annan veterinärmedicin

Publikationens identifierare

DOI: https://doi.org/10.1186/ar4157

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/50356